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Roderick MacKinnon (American neuroscientist)
Roderick MacKinnon (Amerikaans biochemicus)
Roderick MacKinnon (biochemik amerykański, noblista)
Roderick MacKinnon (biochimico e medico statunitense)
Roderick MacKinnon (US-amerikanischer Biochemiker und Mediziner, Nobelpreisträger für Chemie)
Agitoxin footprinting the Shaker potassium channel pore
Atomic structure of a voltage-dependent K super(+) channel in a lipid membrane-like environment
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
barium site in a potassium channel by x-ray crystallography., The
Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel.
Chemistry of ion coordination and hydration revealed by a K super(+) channel-Fab complex at 2.0 angstrom resolution
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Angstrom resolution
conductance maximum observed in an inward-rectifier potassium channel., A
Construction of a cyclic nucleotide-gated KcsA K+ channel.
Contribution of the S4 segment to gating charge in the Shaker K+ channel.
Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain.
Crystal structure and mechanism of a calcium-gated potassium channel.
Crystal structure of a Kir3.1-prokaryotic Kir channel chimera
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K super(+) Channel
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K⁺ Channel.
Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution
Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
Determination of the subunit stoichiometry of a voltage-activated potassium channel.
Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1
Divalent cation selectivity in a cyclic nucleotide-gated ion channel
Electron microscopic analysis of KvAP voltage-dependent K sub(+) channels in an open conformation
Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel.
Energetic optimization of ion conduction rate by the K super(+) selectivity filter
Energetic optimization of ion conduction rate by the K+ selectivity filter
Energetics of pore opening in a voltage-gated K(+) channel.
Functional analysis of an archaebacterial voltage-dependent K+ channel.
Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers.
Functional Reconstitution of Purified Human Hv1 H super(+) Channels
Functional reconstitution of purified human Hv1 H+ channels.
Functional stoichiometry of Shaker potassium channel inactivation.
Gating Charge Transfer Center in Voltage Sensors, A
gating model for the archeal voltage-dependent K(+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers., A
Gating the selectivity filter in CIC chloride channels
Gating the Selectivity Filter in ClC Chloride Channels
Glycine as a D-amino acid surrogate in the K+-selectivity filter
Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites.
Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel
Inferred motions of the S3a helix during voltage-dependent K+ channel gating.
Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor.
inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula, An
Ion binding affinity in the cavity of the KcsA potassium channel.
Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation
Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel.
Lipids in the structure, folding, and function of the KcsA K+ channel.
Localization of the voltage-sensor toxin receptor on KvAP.
Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor.
Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels.
membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom, A
Membrane Protein Insertion and Stability
Molecular basis of K+ conduction and selectivity in potassium channels, 1999:
Mutant KcsA K super(+) Channel with Altered Conduction Properties and Selectivity Filter Ion Distribution, A
Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels.
New insights into the structure and function of potassium channels.
New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins, The
occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates., The
open pore conformation of potassium channels., The
Phospholipids and the origin of cationic gating charges in voltage sensors
Pore loops: An emerging theme in ion channel structure
Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors.
Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture).
principle of gating charge movement in a voltage-dependent K+ channel., The
Principles of Selective Ion Transport in Channels and Pumps
Probing a potassium channel pore with an engineered protonatable site.
Prokaryotes offer hope for potassium channel structural studies.
Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA.
Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom.
Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom.
Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.
Semisynthesis and folding of the potassium channel KcsA.
Semisynthesis of a functional K+ channel.
Snake Toxin Inhibitor of Inward Rectifier Potassium Channel ROMK1, A
Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP.
Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry.
Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.
Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel.
Structural and thermodynamic properties of selective ion binding in a K+ channel.
Structural biology. Membrane protein insertion and stability.
Structural biology. Voltage sensor meets lipid membrane.
Structural conservation in prokaryotic and eukaryotic potassium channels.
Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle
Structure of a Voltage-Dependent K super(+) Channel beta Subunit
Structure of a voltage-dependent K+ channel beta subunit.
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 Å Resolution
Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane
structure of the potassium channel: Molecular basis of K super(+) conduction and selectivity, The
structure of the potassium channel: molecular basis of K+ conduction and selectivity., The
Structure of the RCK Domain from the E. coli K super(+) Channel and Demonstration of Its Presence in the Human BK Channel
Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.
Transfer of the scorpion toxin receptor to an insensitive potassium channel
Two identical noninteracting sites in an ion channel revealed by proton transfer
Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels.
Using mutagenesis to study potassium channel mechanisms.
Voltage-dependent K super(+) channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane
Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane.
Voltage Sensor Meets Lipid Membrane
Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling
X-ray structure of a CIC chloride channel at 3.0 angstrom reveals the molecular basis of anion selectivity
X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.
X-ray structure of a voltage-dependent K+ channel
Contributed to or performed:
NEURON -CAMBRIDGE MA-