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0000 0001 1710 6336
Bert Vogelstein (American oncologist)
Bert Vogelstein (Amerikaans oncoloog)
Bert Vogelstein (US-amerikanischer Krebsforscher)
Howard Hughes Medical Institute
Kinzler, Kenneth W.
Sutherland Media Productions
Zoghbi, Huda Y.
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
14-3-3 sigma is required to prevent mitotic catastrophe after DNA damage
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Absence of secretory phospholipase A2 gene alterations in human colorectal cancer.
Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences.
Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Allelic loss of chromosome 18q and prognosis in colorectal cancer
Allelic Variation in Human Gene Expression
Allelotype of colorectal carcinomas.
ALTERATIONS IN DNA METHYLATION IN COLONIC ADENOCARCINOMA
Altered telomeres in tumors with ATRX and DAXX mutations.
Amplification of a gene encoding a p53-associated protein in human sarcomas.
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Analysing uncharted transcriptomes with SAGE
Analysis of masked mutations in familial adenomatous polyposis.
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients.
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.
Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts.
Antisense Transcriptomes of Human Cells, The
APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis.
APC gene product in normal and tumor cells., The
APC mutations in colorectal tumors with mismatch repair deficiency.
APC mutations occur early during colorectal tumorigenesis.
Apoptosis and APC in colorectal tumorigenesis.
Assessing tumors in living animals through measurement of urinary beta -human chorionic gonadotropin
Association between wild type and mutant APC gene products
Association of the APC tumor suppressor protein with catenins
Bacterial Protein Enhances the Release and Efficacy of Liposomal Cancer Drugs, A
Bacteriolytic therapy can generate a potent immune response against experimental tumors.
BEAMing : single-molecule PCR on microparticles in water-in-oil emulsions
BEAMing up for detection and quantification of rare sequence variants
beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression., The
Can chromosomal instability initiate tumorigenesis?
Cancer drug screen based on cell cycle uncoupling
Cancer drug screen based on cell cycle upcoupling
Cancer genes and the pathways they control
Cancer therapy meets p53
Carcinogen-specific induction of genetic instability
Carcinogens Leave Fingerprints
Carrier detection in X-linked agammaglobulinemia by analysis of X-chromosome inactivation.
CDX2 is mutated in a colorectal cancer with normal APC/ beta -catenin signaling
Cell-cycle arrest versus cell death in cancer therapy
Cell surface tumor endothelial markers are conserved in mice and humans.
Characterization of Human FAST-1, a TGF beta and Activin Signal Transducer
Characterization of MAD2B and other mitotic spindle checkpoint genes.
Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.
Characterization of the yeast transcriptome
Chk2 tumor suppressor is not required for p53 responses in human cancer cells., The
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas.
Chromosome 18Q loss and prognosis in colorectal cancer
Chromosome I8Q loss and prognosis in colorectal cancer
Circulating mutant DNA to assess tumor dynamics.
CLONAL ANALYAIA OF HUMAN NEOPLASIA
Clonal analysis of human colorectal tumors.
CLONAL ANALYSIS OF HUMAN NEOPLASIA
Clonal analysis using recombinant DNA probes from the X-chromosome.
Clonal expansion of p53 mutant cells is associated with brain tumour progression.
Clonal origin bladder cancer.
cMYC is regulated by Tcf-4
Colorectal cancer and the intersection between basic and clinical research.
Colorectal cancer: Mutations in a signalling pathway
colorectal microRNAome, The
Combination bacteriolytic therapy for the treatment of experimental tumors.
Combinatorial chemoprevention of intestinal neoplasia
Comparative lesion sequencing provides insights into tumor evolution
consensus coding sequences of human breast and colorectal cancers., The
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Contribution of bone marrow-derived endothelial cells to human tumor vasculature
Conversion of diploidy to haploidy.
Converting cancer genes into killer genes
Converting diploidy to haploidy for genetic diagnosis
Cooperative effects of genes controlling the G sub(2)/M checkpoint
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Counting alleles reveals a connection between chromosome 18q loss and vascular invasion.
Counting alleles to predict recurrence of early-stage colorectal cancers.
CpG methylation is maintained in human cancer cells lacking DNMT1
Cytogenetics and molecular genetics: their status and role in understanding the behavior of central nervous system neoplasms.
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
DCC gene product in cellular differentiation and colorectal tumorigenesis, The
DCC gene: structural analysis and mutations in colorectal carcinomas., The
DEC1 is a downstream target of TGF- beta with sequence-specific transcriptional repressor activities
Definition of a consensus binding site for p53.
Design and analysis issues in genome-wide somatic mutation studies of cancer.
Detecting colorectal cancer in stool with the use of multiple genetic targets.
Detection and quantification of mutations in the plasma of patients with colorectal tumors
Detection of APC mutations in fecal DNA from patients with colorectal tumors
Detection of loss of the wild-type P53 gene and kits therefor
Detection of proximal colorectal cancers through analysis of faecal DNA.
Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of DMXAA in human and mouse plasma.
Diagnostic method detecting loss of wild-type p53
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
DNA methylation and genetic instability in colorectal cancer cells
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia.
EcoRI polymorphism within the GLI gene (chromosome 12q13.3-14.1)
Endothelial cell expression patterns
Epitope landscape in breast and colorectal cancer.
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms., An
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene.
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells
Founding mutations and Alu-mediated recombination in hereditary colon cancer
Frequency of Smad gene mutations in human cancers.
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
Gatekeepers and caretakers
GENE AMPLIFICATION IN TUMORS OF THE NERVOUS SYSTEM
Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.
Gene expression profiles in normal and cancer cells.
Genes expressed in human tumor endothelium
Genetic alterations during colorectal-tumor development.
genetic basis of human cancer, The
Genetic determinants of p53-induced apoptosis and growth arrest
Genetic disruption of PPAR delta decreases the tumorigenicity of human colon cancer cells
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
Genetic instabilities in human cancers
Genetic instability in colorectal cancers.
Genetic knockouts and knockins in human somatic cells.
genetic landscape of the childhood cancer medulloblastoma., The
genetic model for colorectal tumorigenesis., A
Genetic progression and the waiting time to cancer
Genetic testing--presenting and future
Genetics. Please don't call it cloning!
genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT, The
genomic landscapes of human breast and colorectal cancers., The
Genomic organization of the human PMS2 gene family.
Genotyping by mass spectrometric analysis of short DNA fragments.
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.
GermlineSMAD4 orBMPRIA mutations and phenotype of juvenile polyposis
GLI gene encodes a nuclear protein which binds specific sequences in the human genome., The
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells.
Going mad with Smads
Has the breast cancer gene been found?
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
High frequency of mutations of the PIK3CA gene in human cancers.
HindIII polymorphism in the DCC gene
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
Homozygous p53 gene-defective human colonic cell line
Human fast-1 gene
Human fast-1 protein
Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae.
Human Smad3 and Smad4 are sequence-specific transcription activators.
Hyper-recombination and genetic instability in BLM-deficient epithelial cells.
Hypomethylation of DNA from benign and malignant human colon neoplasms.
Identification and classification of p53-regulated genes
Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Identification of an amplified, highly expressed gene in a human glioma.
Identification of c-MYC as a target of the APC pathway
Identification of CDK4 as a target of c-MYC
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells.
Identification of FAP locus genes from chromosome 5q21.
Identification of p53 as a sequence-specific DNA-binding protein.
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
IDH1 and IDH2 mutations in gliomas.
Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro- beta -D-arabinofuranosyl)-5-iodouracil
In vivo cloning of PCR products in E. coli.
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.
Inactivation of both APC alleles in human and mouse tumors
Inactivation of hCDC4 can cause chromosomal instability.
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Infrequent p53 gene mutations in medulloblastomas.
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.
Integrated Genomic Analysis of Human Glioblastoma Multiforme., An
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response.
Knudson's hypothesis and the TP53 revolution.
Landscaping the Cancer Terrain
Learning from patients : the science of medicine
Lessons from hereditary colorectal cancer
Life (and death) in a malignant tumour
Localization of SV40 genes within supercoiled loop domains.
Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics
Mad-related genes in the human.
Mammalian cells resistant to tumor suppressor genes.
Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse
Mechanisms underlying losses of heterozygosity in human colorectal cancers.
Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis.
Method for serial analysis of gene expression
Methods for restoring wild-type p53 gene function
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.
Mismatch repair deficiency in phenotypically normal human cells
MITOTIC INDUCING PROTEIN (S) FROM MAMMALIAN CELLS
model for p53-induced apoptosis., A
Molecular cloning of the N-terminus of GTBP
Molecular diagnosis of familial adenomatous polyposis.
Molecular Genetic Analysis of Colorectal Cancer
molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18., A
Mono-allelic mutation analysis for identifying germline mutations
Monoallelic mutation analysis (MAMA) for identifying germline mutations.
Multicolor in vitro translation.
multidimensional analysis of genes mutated in breast and colorectal cancers., A
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.
multistep nature of cancer., The
Mutant p53 proteins bind DNA abnormally in vitro.
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Mutant proteins as cancer-specific biomarkers
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma.
Mutational Analysis of the APC/ beta -Catenin/Tcf Pathway in Colorectal Cancer
Mutational analysis of the tyrosine kinome in colorectal cancers.
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Mutational Inactivation of Transforming Growth Factor beta Receptor Type II in Microsatellite Stable Colon Cancers
Mutations of mitotic checkpoint genes in human cancers
Mutator gene and hereditary non-polyposis colorectal cancer
Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12.
naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype., A
NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells.
Oncogenic forms of p53 inhibit p53-regulated gene expression.
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
Opinion: The significance of unstable chromosomes in colorectal cancer
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria.
p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest
p53 function and dysfunction
P53 GENE IN HUMAN NEOPLASIA, THE
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
p53 mutations in human cancers.
p53 tagged sites from human genomic DNA.
PAK1, a gene that can regulate p53 activity in yeast.
panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53, A
Paradoxical inhibition of solid tumor cell growth by bcl2
Participation of p53 protein in the cellular response to DNA damage.
Pharmacologic and Toxicologic Evaluation of C. novyi-NT Spores
Phenotypic Analysis of hMSH2 Mutations in Mouse Cells Carrying Human Chromosomes
phosphatase associated with metastasis of colorectal cancer., A
Phosphorylation of beta-catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells.
Please don't call it cloning!
Polymerase delta variants in RER colorectal tumours.
Prevalence of ras gene mutations in human colorectal cancers.
Prevalence of somatic alterations in the colorectal cancer cell genome.
PRL-3 expression in metastatic cancers.
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
protocol for rapid generation of recombinant adenoviruses using the AdEasy system, A
Public Database for Gene Expression in Human Cancers, A
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
RAF/RAS oncogenes and mismatch-repair status
RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study.
Requirement for p53 and p21 to sustain G2 arrest after DNA damage.
Role of BAX in the apoptotic response to anticancer agents.
role of chromosomal instability in tumor initiation., The
role of companion diagnostics in the development and use of mutation-targeted cancer therapies, The
Securin is required for chromosomal stability in human cells.
Selective expression of desired genes in cells expressing oncoproteins
Sensitive digital quantification of DNA methylation in clinical samples
Sequence-specific transcriptional activation is essential for growth suppression by p53
Serial analysis of gene expression
Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA
Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers.
Short Mononucleotide Repeat Sequence Variability in Mismatch Repair-deficient Cancers
significance of unstable chromosomes in colorectal cancer., The
Similarity of the DNA-damage responsiveness and growth-suppressive properties of WAF1/CIP1 and GADD45
simplified system for generating recombinant adenoviruses, A
SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells.
Small changes in expression affect predisposition to tumorigenesis
Somatic Mutations of EGFR in Colorectal Cancers and Glioblastomas
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers
Somatic mutations of the mitochondrial genome in human colorectal tumours
Specific p53 Mutations Detected in Plasma and Tumors of Hepatocellular Carcinoma Patients by Electrospray Ionization Mass Spectrometry
Spore Coat Architecture of Clostridium novyi NT Spores
Structural alterations of the epidermal growth factor receptor gene in human gliomas.
Structural comparisons of class I phosphoinositide 3-kinases.
Structure of a Human p110[alpha]/p85[alpha] Complex Elucidates the Effects of Oncogenic PI3K[alpha] Mutations, The
structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations., The
Subtle mitochondrial mutations as tumor markers
Supercoiled loops and eucaryotic DNA replicaton.
Suppression of human colorectal carcinoma cell growth by wild-type p53.
Surfing the p53 network
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
Targeted inactivation of CTNNB1 reveals unexpected effects of beta -catenin mutation
Targeted inactivation of p53 in human cells does not result in aneuploidy.
TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).
Three classes of genes mutated in colorectal cancers with chromosomal instability.
Top-down morphogenesis of colorectal tumors.
Transforming Growth Factor- beta -induced Growth Inhibition in a Smad4 Mutant Colon Adenoma Cell Line
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
Tumour-suppressor genes. X-rays strike p53 again.
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
Use of isogenic human cancer cells for high-throughput screening and drug discovery
Using the transcriptome to annotate the genome
WAF1, a potential mediator of p53 tumor suppression.
What's mice got to do with it?
Wild-type but not mutant APC associates with the microtubule cytoskeleton
Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.
zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A., The
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