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Brown, P. O.
Brown, Patrick O.
Brown, Patrick O'Reilly,
Patrick Brown
Patrick O. Brown (American biochemist)
Patrick O. Brown (Amerikaans biochemicus)
Patrick O. Brown (US-amerikanischer Biochemiker)
פטריק בראון
پاتریک براون
Creation class: 
Creation role: 
Related names: 
University of Chicago, Dept. of Biochemistry
2005 Curt Stern Award address. Exploring along a crooked path.
3'-end processing and kinetics of 5'-end joining during retroviral integration in vivo.
Adaptation to famine: A family of stationary-phase genes revealed by microarray analysis
Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays.
Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs
Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans.
Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae.
Autoantigen microarrays for multiplex characterization of autoantibody responses.
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
Building a "GenBank" of the published literature.
Cancer characterization and feature set extraction by discriminative margin clustering.
Catenation and knotting of duplex DNA by type 1 topoisomerases: a mechanistic parallel with type 2 topoisomerases.
Cell-type specific gene expression profiles of leukocytes in human peripheral blood.
Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae.
Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer
Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations.
Characterization of recombinant murine leukemia virus integrase.
Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae
Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types
Cluster analysis and display of genome-wide expression patterns.
Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes
Comparative Analysis of Viral Gene Expression Programs during Poxvirus Infection: A Transcriptional Map of the Vaccinia and Monkeypox Genomes
Comparative Gene Expression Profiles Following UV Exposure in Wild-Type and SOS-Deficient Escherichia coli
Comparative genome-scale analysis of gene expression profiles in T cell lymphoma cells during malignant progression using a complementary DNA microarray.
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.
Comprehensive mutational analysis of the Moloney murine leukemia virus envelope protein.
Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA.
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase.
core domain of HIV-1 integrase recognizes key features of its DNA substrates, The
Correct integration of retroviral DNA in vitro.
Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes.
Degradation of Proteins from the ER of S. cerevisiae Requires an Intact Unfolded Protein Response Pathway
Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays.
Desferrioxamine-mediated Iron Uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake
Detection and Characterization of Cellular Immune Responses Using Peptide-MHC Microarrays
Determination of Stromal Signatures in Breast Carcinoma
Development of the human infant intestinal microbiota.
Differential gene expression in anatomical compartments of the human eye.
Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor.
Discovery and validation of breast cancer subtypes.
Disruption of the terminal base pairs of retroviral DNA during integration
Dissecting eukaryotic translation and its control by ribosome density mapping
Dissecting fundamental mechanisms of protein translation in Saccharomyces cerevisiae, 2013:
Dissecting interferon-induced transcriptional programs in human peripheral blood cells.
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.
Diverse and specific gene expression responses to stresses in cultured human cells.
Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System
Diversity of gene expression in adenocarcinoma of the lung
Diversity, topographic differentiation, and positional memory in human fibroblasts.
DNA arrays for analysis of gene expression.
DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines.
DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli.
DNA microarray survey of gene expression in normal human tissues., A
DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization., A
DNA strand exchange and selective DNA annealing promoted by the human immunodeficiency virus type 1 nucleocapsid protein.
Drug target validation and identification of secondary drug target effects using DNA microarrays
Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzyme-substrate interactions.
Endothelial cell diversity revealed by global expression profiling.
Energy coupling in DNA gyrase and the mechanism of action of novobiocin.
Enrichment for Loci Identical-by-Descent between Pairs of Mouse or Human Genomes by Genomic Mismatch Scanning
essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer, An
Examining the living genome in health and disease with DNA microarrays
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
Exploring the metabolic and genetic control of gene expression on a genomic scale
Exploring the new world of the genome with DNA microarrays.
Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments.
Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome.
Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast
Functional analysis of the genes of yeast chromosome V by genetic footprinting
Functional characterization of the human immunodeficiency virus type 1 genome by genetic footprinting.
Functional genomic analysis of a commercial wine strain of Saccharomyces cerevisiae under differing nitrogen conditions.
Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent.
gene expression database for the molecular pharmacology of cancer., A
Gene expression in the normal adult human kidney assessed by complementary DNA microarray.
Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans.
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors.
Gene Expression Patterns in Human Liver Cancers
Gene expression patterns in human placenta
Gene expression patterns in ovarian carcinomas.
Gene expression patterns in pancreatic tumors, cells and tissues.
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Gene-expression patterns reveal underlying biological processes in Kawasaki disease
Gene expression profiling identifies clinically relevant subtypes of prostate cancer.
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
gene-expression program reflecting the innate immune response of cultured intestinal epithelial cells to infection by Listeria monocytogenes., A
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns.
Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms
Genetic footprinting: a genomic strategy for determining a gene's function given its sequence.
Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants.
Genome-Scale Identification of Membrane-Associated Human mRNAs
Genome-wide analysis of DNA copy-number changes using cDNA microarrays.
Genome-wide Analysis of Gene Expression Regulated by the Calcineurin/Crz1p Signaling Pathway in Saccharomyces cerevisiae
Genome-wide analysis of mRNA lengths in Saccharomyces cerevisiae.
Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae.
Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast.
Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster
Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin
Genomewide view of gene silencing by small interfering RNAs.
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF.
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Genomic expression programs in the response of yeast cells to environmental changes.
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.
Genomic mismatch scanning: a new approach to genetic linkage mapping.
Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli.
Genomics and human disease--variations on variation.
Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source.
Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae
Haa1, a Protein Homologous to the Copper-regulated Transcription Factor Ace1, Is a Novel Transcriptional Activator
High-resolution functional mapping of a cloned gene by genetic footprinting.
host response to smallpox: Analysis of the gene expression program in peripheral blood cells in a nonhuman primate model, The
Host sequences flanking the HIV provirus.
Human immunodeficiency virus integration in a cell-free system.
Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray.
Identification of genes periodically expressed in the human cell cycle and their expression in tumors.
Identification of RNA recognition elements in the Saccharomyces cerevisiae transcriptome.
Identification of the Copper Regulon in Saccharomyces cerevisiae by DNA Microarrays
In vivo regulation of human skeletal muscle gene expression by thyroid hormone.
Inaugural article: global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.
Individuality and variation in gene expression patterns in human blood.
Information access. Building a "GenBank" of the published literature.
Integration of murine leukemia virus DNA depends on mitosis.
interview with Patrick O Brown on the origins and future of open access, An
Juxtaposition of two viral DNA ends in a bimolecular disintegration reaction mediated by multimers of human immunodeficiency virus type 1 or murine leukemia virus integrase.
landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells, A
Large-scale identification of secreted and membrane-associated gene products using DNA microarrays
lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes., The
Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking.
Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray
Mediator protein mutations that selectively abolish activated transcription.
method for detecting and correcting feature misidentification on expression microarrays., A
Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors.
Microarrays in primary breast cancer--lessons from chemotherapy studies.
Minimizing off-target effects by using diced siRNAs for RNA interference.
Missing value estimation methods for DNA microarrays
Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
Molecular characterisation of soft tissue tumours: a gene expression study.
Molecular portraits of human breast tumours.
Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping and differential effects on integrase activities in vitro.
New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.
Nonparametric methods for identifying differentially expressed genes in microarray data.
novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status., The
nucleoprotein complex mediates the integration of retroviral DNA., A
Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas
Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes
Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer.
Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.
Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex.
Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays.
Precision and functional specificity in mRNA decay.
preclinical natural history of serous ovarian cancer: defining the target for early detection., The
Predicting a local recurrence after breast-conserving therapy by gene expression profiling.
Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway.
Probing lymphocyte biology by genomic-scale gene expression analysis.
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association
Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions.
Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae
Public-access group supports PubMed Central
Quantitative monitoring of gene expression patterns with a complementary DNA microarray
Rapid quantitative profiling of complex microbial populations
Regulation of CSF1 Promoter by the SWI/SNF-like BAF Complex
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia.
Repeated observation of breast tumor subtypes in independent gene expression data sets.
RERG Is a Novel ras-related, Estrogen-regulated and Growth-inhibitory Gene in Breast Cancer
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.
Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus.
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae.
second iron-regulatory system in yeast independent of Aft1p, A
Sequence requirements for efficient translational frameshifting in the Escherichia coli dnaX gene and the role of an unstable interaction between tRNA(Lys) and an AAG lysine codon.
Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria.
sign inversion mechanism for enzymatic supercoiling of DNA., A
Singular value decomposition for genome-wide expression data processing and modeling
SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data.
specific gene expression program triggered by Gram-positive bacteria in the cytosol, A
stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro, A
Stanford Microarray Database accommodates additional microarray platforms and data formats., The
Stanford Microarray Database: data access and quality assessment tools., The
Stanford Microarray Database: implementation of new analysis tools and open source release of software., The
Stanford Tissue Microarray Database., The
Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent
Stereospecificity of Reactions Catalyzed by HIV-1 Integrase
Stereotyped and specific gene expression programs in human innate immune responses to bacteria.
Structure and activities of Escherichia coli DNA gyrase.
Studies on DNA topoisomerases, 1980
Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus.
Substrate features important for recognition and catalysis by human immunodeficiency virus type 1 integrase identified by using novel DNA substrates.
Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: implications for retroviral assembly mechanisms.
Systematic changes in gene expression patterns following adaptive evolution in yeast.
Systematic Evaluation of Candidate Blood Markers for Detecting Ovarian Cancer
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance.
Systematic variation in gene expression patterns in human cancer cell lines.
Systemic and cell type-specific gene expression patterns in scleroderma skin.
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever, The
Three Cell Wall Mannoproteins Facilitate the Uptake of Iron in Saccharomyces cerevisiae
Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function
Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology.
topoisomerase from Escherichia coli related to DNA gyrase., A
Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro.
transcriptional program in the response of human fibroblasts to serum, The
Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments.
transcriptional program of sporulation in budding yeast., The
Transcriptional programs activated by exposure of human prostate cancer cells to androgen.
Transcriptional Remodeling in Response to Iron Deprivation in Saccharomyces cerevisiae
Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11.
transcriptional response to Wnt protein in human embryonic carcinoma cells., A
Transduction of Human Progenitor Hematopoietic Stem Cells by Human Immunodeficiency Virus Type 1-Based Vectors Is Cell Cycle Dependent
Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes.
Two-dimensional crystallization of histidine-tagged, HIV-1 reverse transcriptase promoted by a novel nickel-chelating lipid.
Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth.
Use of a cDNA microarray to analyse gene expression patterns in human cancer
Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression
Variation in gene expression patterns in follicular lymphoma and the response to rituximab.
Variation in gene expression patterns in human gastric cancers.
Virtual Northern analysis of the human genome.
Visualizing associations between genome sequences and gene expression data using genome-mean expression profiles.
Whole-genome expression analysis of snf/swi mutants of Saccharomyces cerevisiae.
Why PLoS became a publisher.
Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis.
Yeast microarrays for genome wide parallel genetic and gene expression analysis
Contributed to or performed: 
Thesis (Ph. D.)--University of Chicago, Dept. of Biochemistry, December 1980