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0000 0000 8483 6657
Elledge, S. J.
Elledge, Stephen J.
Elledge, Stephen Joseph
Stephen Elledge (Amerikaans klinische genetica)
Stephen Elledge (Professor of genetics)
Stephen J. Elledge (US-amerikanischer Genetiker)
Friedberg, Errol C.
Lehmann, Alan R.
Lindahl, T. (1938-)
Lindahl, Tomas (1938-)
Massachusetts Institute of Technology, Dept. of Biology
Muzi-Falconi, Marco (1965-)
53BP1, a mediator of the DNA damage checkpoint
53BP1 oligomerization is independent of its methylation by PRMT1.
Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
Abstracts of papers presented at the 2002 meeting on the cell cycle, 2002:
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Analysis of budding yeast kinases controlled by DNA damage.
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression, The
Asf1 links Rad53 to control of chromatin assembly.
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency
ATR and ATRIP: partners in checkpoint signaling.
Autoantigen discovery with a synthetic human peptidome.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit., The
BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients., The
BRCA2 enters the fray
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
Cancer: BRCA2 Enters the Fray
Cancer: Deconstructing oncogenesis.
Cancer proliferation gene discovery through functional genomics.
Cdk inhibitors in development and cancer.
Cdk inhibitors: on the threshold of checkpoints and development.
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Cell biology forum: Genome-wide view of mitosis
Cell cycle checkpoints: preventing an identity crisis.
Checking on the fork: the DNA-replication stress-response pathway.
Chk1 is an essential kinase that is regulated by Atr and required for the G sub(2)/M DNA damage checkpoint
Chk1 is haploinsufficient for multiple functions critical to tumor suppression.
Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner
chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage, A
Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli
Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.
Cooperation between the Cdk inhibitors p27 super(KIP1) and p57 super(KIP2) in the control of tissue growth and development
Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.
Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.
Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.
Cyclin D1 provides a link between development and oncogenesis in the Retina and the Breast
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
Cyclin F Disruption Compromises Placental Development and Affects Normal Cell Cycle Execution
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.
Design of 240,000 orthogonal 25mer DNA barcode probes
Dicer is essential for mouse development
Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.
Direct DNA binding by Brca1
Dissecting cancer pathways and vulnerabilities with RNAi.
Dissection of a molecular switch that senses DNA damage
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
DNA damage and cell cycle regulation of ribonucleotide reductase.
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
DNA damage induction of ribonucleotide reductase.
DNA damage response: making it safe to play with knives., The
DNA damage response: Putting checkpoints in perspective, The
DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling, A
DNA damage response: ten years after., The
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint
DNA repair, mutagenesis, and other responses to DNA damage : a subject collection from Cold Spring Harbor perspectives in biology
DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor, The
Dominant genetics using a yeast genomic library under the control of a strong inducible promoter.
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.
DUN1 encodes a protein kinase that controls the DNA damage response in yeast.
Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
F-Box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
family of mammalian F-box proteins., A
family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast., A
family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae., A
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.
Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair, The
Finding prospective partners in the library: the two-hybrid system and phage display find a match.
functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling, A
Functional identification of optimized RNAi triggers using a massively parallel sensor assay.
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts.
Gene identification using the yeast two-hybrid system.
Gene targeting at the human CD4 locus by epitope addition.
Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.
Genetic and Physical Interactions Between DPB11 and DDC1 in the Yeast DNA Damage Response Pathway
Genetic imprinting and cancer
genetic screen for candidate tumor suppressors identifies REST., A
genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair., A
genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability, A
Genetic selection for genes encoding sequence-specific DNA-binding proteins.
Genetics of cell cycle and DNA damage regulation in yeast
genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability., A
genome-wide genetic screen for host factors required for hepatitis C virus propagation, A
genome-wide RNAi screen identifies a new transcriptional module required for self-renewal., A
genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene., A
Genome-wide view of mitosis
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.
Genomic instability and endoreduplication triggered by RAD17 deletion.
Global Protein Stability Profiling in Mammalian Cells
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC
How ATR turns on: TopBP1 goes on ATRIP with ATR
How the Cyclin Became a Cyclin: Regulated Proteolysis in the Cell Cycle
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.
Human cyclin F
Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway.
Identification and characterization of genes ... 1983
IDENTIFICATION AND CHARACTERIZATION OF GENES INVOLVED IN MUTAGENESIS IN ESCHERICHIA COLI, THE
Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability.
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.
Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae
Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling
Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus, The
Inhibition of cyclin-dependent kinases by p21.
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system.
Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae.
Lambda gt 11: gene isolation with antibody probes and other applications.
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.
lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells, A
Lessons from Nature: microRNA-based shRNA libraries
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
Mitotic arrest: Mad2 prevents sleepy from waking up the APC
mitotic spindle is required for loading, of the DASH complex onto the kinetochore, The
Mitotic treasures in the nucleolus
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.
Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork
Mrc1 transduces signals of DNA replication stress to activate Rad53
Multiple tumor suppressor pathways negatively regulate telomerase.
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1., A
New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability
Non-oncogene addiction and the stress phenotype of cancer cells.
Open Letter to Cancer Researchers, An
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
p21 super(CIP1) and p57 super(KIP2) control muscle differentiation at the myogenin step
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle
Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function
Phosphorylation-dependent ubiquitination of cyclin E by the SCF super(Fbw7) ubiquitin ligase
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
PICK1: A perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system
pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo, The
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
Position and density effects on repression by stationary and mobile DNA-binding proteins.
Principles of cancer therapy: oncogene and non-oncogene addiction.
Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate
Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53
Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome., The
Purification and analysis of CIP/KIP proteins.
quantitative atlas of mitotic phosphorylation, A
Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae
Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast
Rapid construction of recombinant DNA by the univector plasmid-fusion system.
Rapid mapping of antigenic coding regions and constructing insertion mutations in yeast genes by mini-Tn10 "transplason" mutagenesis.
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Recognition of Phosphodegron Motifs in Human Cyclin E by the SCF super(Fbw7) Ubiquitin Ligase
Reconstitution of G sub(1) cyclin ubiquitination with complexes containing SCF super(Grr1) and Rbx1
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.
Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle Checkpoints
Replication protein A-mediated recruitment and activation of Rad17 complexes
Requirement of ATM-dependent phosphorylation of Brca 1 in the DNA damage response to double-strand breaks
Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
resource for large-scale RNA-interference-based screens in mammals., A
Ribonucleotide reductase: regulation, regulation, regulation.
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
RNA interference screen for human genes associated with West Nile virus infection.
Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability
Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response, A
role of Cdk7 in CAK function, a retro-retrospective, The
role of KIP2 in breast cancer, The
role of protein stability in the cell cycle and cancer., The
Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment., The
SAD1/RAD53 protein kinase controls multiple cell cycle checkpoints and DNA damage induced transcription in yeast, The
SCF super( beta -TRCP) links Chk1 signaling to degradation of the Cdc25A protein phosphatase
SCF super( beta -TRCP)-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in I Kappa B alpha and beta -catenin and stimulates I Kappa B alpha ubiquitination in vitro, The
SCF super(bold beta-TRCP) controls oncogenic transformation and neural differentiation through REST degradation
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro., The
Second-generation shRNA libraries covering the mouse and human genomes
Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
SGT1 Encodes an Essential Component of the Yeast Kinetochore Assembly Pathway and a Novel Subunit of the SCF Ubiquitin Ligase Complex
SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart., The
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-Box
Specific association between the human DNA repair proteins XPA and ERCC1.
Stopped for repairs.
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway
SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II., The
Synthetic design of strong promoters
Systematic analysis and nomenclature of mammalian F-box proteins.
Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function
Transcriptional regulation and function during the human cell cycle
Troponin T is capable of binding dystrophin via a leucine zipper.
tumor suppressor CYLD regulates entry into mitosis., The
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
ubiquitin-specific protease USP28 is required for MYC stability, The
univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes, The
Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
Contributed to or performed:
CELL -CAMBRIDGE MA-
GENES AND DEVELOPMENT
METHODS IN ENZYMOLOGY
MOLECULAR AND CELLULAR BIOLOGY
PROCEEDINGS- NATIONAL ACADEMY OF SCIENCES USA
SCIENCE -NEW YORK THEN WASHINGTON-
Supervised by Graham C. Walker
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1983