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0000 0001 2453 0258
Schofield, C. J.
University of Oxford
1-Aminocyclopropane-1-carboxylate oxidase: molecular structure and catalytic function.
Active Site Mutations of Recombinant Deacetoxycephalosporin C Synthase
Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans .
Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Chemical and enzymatic synthesis of beta-lactam antibiotics
Chemistry and biosynthesis of clavulanic acid and other clavams.
Comments on the use of a dichromophoric circular dichroism assay for the identification of beta-turns in peptides.
Controlling the Substrate Selectivity of Deacetoxycephalosporin/deacetylcephalosporin C Synthase
Crystal Structure and Mechanistic Implications of N super(2)-(2- Carboxyethyl)arginine Synthase, the First Enzyme in the Clavulanic Acid Biosynthesis Pathway
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium
Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
Delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: isolation of L-cysteinyl-D-valine, a 'shunt' product, and implications for the order of peptide bond formation.
effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus., The
Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis.
Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli.
Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases
fate of valine-oxygen during penicillin biosynthesis., The
fluorescence-based assay for 2-oxoglutarate-dependent oxygenases., A
Glyco- and Peptidomimetics from Three-Component Joullie-Ugi Coupling Show Selective Antiviral Activity
High level expression in Escherichia coli of a fungal gene under the control of strong promoters.
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
Inactivation of 1-aminocyclopropane-1-carboxylate (ACC) oxidase.
Inactivation of 1-aminocyclopropane-1-carboxylate oxidase involves oxidative modifications.
Inhibition of 1-aminocyclopropane-1-carboxylate oxidase by 2-oxoacids.
Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.
Inhibition of TEM-2 beta -lactamase from Escherichia coli by clavulanic acid: Observation of intermediates by electrospray ionization mass spectrometry
Inhibitor Thiomandelic Acid Binds to Both Metal Ions in Metallo- beta -lactamase and Induces Positive Cooperativity in Metal Binding, The
Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
Isopenicillin N synthase: A new mode of reactivity.
Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein.
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).
kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase, The
L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation.
Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives.
Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.
Molecular mechanism of the multifunctional enzyme L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase.
Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.
Mutagenesis studies on the iron binding ligands of clavaminic acid synthase.
New Structural Insights into the Inhibition of Serine Proteases by Cyclic Peptides from Bacteria
ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity
Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.
Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase.
Oxidative degradation of bilirubin produces vasoactive compounds.
'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes.
Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
Proteins of the penicillin biosynthesis pathway
Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.
Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis.
Purification, crystallization and preliminary X-ray diffraction of anthocyanidin synthase from Arabidopsis thaliana.
Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha -oxidation
role of alpha -ketoglutarate in cephalosporin biosynthesis., The
role of iron and 2-oxoglutarate oxygenases in signalling., The
Selectivity and Inhibition of AlkB, The
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.
Structural and mechanistic studies on N super(2)-(2-carboxyethyl)arginine synthase
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease.
Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.
Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1[alpha]
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α
Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
Studies on non-haem ferrous-dependent oxygenases and oxidases.
Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A.
Studies on the Active Site of Deacetoxycephalosporin C Synthase
Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase.
Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products.
Targeting of HIF-a to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
Tripeptide LY301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus.
Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta -lactamase catalysis.
X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes.
X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.
Contributed to or performed:
EUROPEAN JOURNAL OF BIOCHEMISTRY